Isco is a distinctive boys' name in United States, ranking #12753 in 2025 with 5 recorded births. This places Isco in the bottom 8% of ranked US boys' names for the year. Its actual usage is classified as Rare. The name reached its all-time peak in 2018 with 9 births ranking #8424. In 2025, approximately 1 in every 341,615 boys born was named Isco. FALLING Recent data shows the name is currently falling.