Karlene is a distinctive girls' name in United States, ranking #7220 in 2008 with 18 recorded births. The name reached its all-time peak in 1996 with 32 births ranking #3533. Since 1996, the popularity has decreased by 43.8%. In 2008, approximately 1 in every 105,040 girls born was named Karlene. RISING Recent data shows the name is currently rising.