Karlene is a distinctive girls' name in United States, ranking #9226 in 2020 with 11 recorded births. The name reached its all-time peak in 1996 with 32 births ranking #3533. Since 1996, the popularity has decreased by 65.6%. In 2020, approximately 1 in every 146,865 girls born was named Karlene. RISING Recent data shows the name is currently rising.